12/27/2023 0 Comments Function of free nerve endings in skin![]() Over the past several decades, there have been significant improvements in TES, with many engineered skin products being developed for clinical usage. The ideal TES should include all of the skin appendages and layers (epidermis and dermis), and establish a functional vascular and nerve network, further promoting scar-free integration into the surrounding host tissue. TES is mainly composed of biomaterials, cells and bioactive factors. Tissue-engineered skin is a new type of tissue graft that can be used to directly treat wounds, induce cell migration, promote vascularisation and epithelisation, and accelerate wound healing. TES constitutes an alternative for wound coverage and tissue reconstruction. However, the shortage of skin donor sites, secondary injury and risk of infection limit the application of autologous skin grafts. Currently, the gold standard treatment for severe skin wounds is autologous skin grafting. Skin wounds caused by various acute and chronic factors, such as burns, surgery and diabetic ulcers, are very common, which imposes a heavy burden on society and the health of the general population (Table 1). The skin is the outmost surface of the human body, and is thus susceptible to damage from the environment. ![]() The functions of the skin include (1) mechanical protection, (2) defence against the environment, (3) immune regulation, (4) body fluid regulation, (5) prevention of water loss from the body, (6) regulation of body temperature and (7) sensing of external stimuli. The skin is composed of the epidermis, dermis and subcutaneous tissue, and is the largest organ of the human body (Fig. This article provides a comprehensive overview of different strategies for, and advances in, skin appendages and sensory nerve regeneration, which is an important issue in the field of tissue engineering and regenerative medicine. Current strategies to create skin appendages and sensory nerve regeneration are mainly based on different types of seeding cells, scaffold materials, bioactive factors and involved signaling pathways. Restoration of pain, temperature, and touch perceptions should now be a major challenge to solve in order to improve patients’ quality of life. However, patients often complain about a loss of skin sensation and even cutaneous chronic pain. ![]() To date, many studies have yielded remarkable results in the field of skin appendages reconstruction and nerve regeneration. Skin appendages and nerves are important constituents for fully functional skin. However, a major drawback of TES products is a lack of skin appendages and nerves to enhance skin healing, structural integrity and skin vitality. Tissue-engineered skin (TES), as an analogue of native skin, is promising for wound repair and regeneration. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |